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variant that phenocopies the human Pro33 variant to elucidate the consequences of constitutively Increased αvβthree signaling to your 5-HT process in the Mind. KI mice shown deficits in a number of behaviors, which includes anxiousness, repetitive, and social behaviors. Anatomical scientific studies revealed a big reduce in five-HT synapses while in the midbrain, accompanied by decreases in SERT activity and minimized localization of SERTs to integrin adhesion complexes in synapses of KI mice.